Product Profile: SciFlow 1000 Culture Device

Author: Mike Collins Dec 3, 2014 Posted in: Blog > News

Three out of four developmental pharmaceuticals fail in late-stage testing, primarily due to an unexpected toxicity or lack of efficacy identified in clinical trials. A new product from Scikon Innovation, developed in collaboration with CADJockey, has the potential to shorten production and testing cycles for proposed pharmaceutical products, improving rates of success and reducing the overall cost of development.

The SciFlow 1000 culture device is a 96-well testing instrument with cascading microfluid flow. A drug sample introduced into an initial well flows gradually into consecutive reservoirs, permitting testing of the chemical transition between successive ‘hosts.’ This situation can be set up to mimic prospective drug interaction with human tissues, introducing a sample initially into saliva and progressing through consecutive organ systems leading into the bloodstream. This generates potential for human reactions to developmental drugs to be determined prior to the late-stage product testing in volunteer human candidates. By making in-vitro and in-vivo benchtop experiments possible, it also offers an alternative to less-effective preliminary testing in animal tissues.

SciKon Innovation approached CADJockey with a rough prototype of the instrument. Our product developers worked from this early-stage concept to devise a product that can be manufactured rapidly in high volume. The product, in beta testing with SciKon clients at the time of this post, is produced in a clean room from injection-molded plastic — polystyrene—the same material as culture plates currently used in pharma research and development.

SciKon Waterfall AssemblyTwo of the most notable qualities of the innovation are the microfluidic channels and the syphon-drive system controlling the flow between wells. This ‘tempered’ flow allows research scientists to evaluate networked relationships between cells, tissue and environments, an advancement from traditional static testing systems.

The tool has the same shape as preexisting 96-well plates, includes a lid, and is compatible with standard laboratory microplate readers and microscopes.

Here is how Scikon describes the product on its You Tube channel:

Cascading flow and multi-organ device. An in vitro cell culture biodevice that consists of wells linked together through microfluidic channels and a syphon-drive system that controls flow through and between wells. The system allows for a “tempered” flow of chemical concentrations through wells either of a single lineage or between multiple lineages. The device advances nutrient transport for ‘cells in system’ approaches, and was designed to retain traditional culture configurations while advancing fluid distributions with grafted flow paths. This affords users the option to evaluate networked -cell, -tissue, and -environment relationships.

For more information on SciFlow, visit the SciKon Innovation website.

About our collaborative partner:  SciKon is known for their unique ability to pioneer human and animal primary cell culture devices into predictive model bio-tools. They work with many of the major pharmaceutical companies, CRO’s, government and academic institutions, with the goal of establishing a long-term, collaborative relationship that provides optimal outcomes.

CADJockey enjoyed the privilege to collaborate with SciKon Innovation on this ground-breaking development for the pharmaceutical industry. Check out our portfolio for products on which we have collaborated with clients in medical, consumer, automotive and industrial industries. We welcome the opportunity to apply our expertise to your product design and development challenge. Contact us today.